Al-Zeini held academic roles, including Vice Dean and Professor at Cairo's Faculty of Fine Arts. He exhibited his work both locally and internationally, with notable shows at the Alexandria Biennale and São Paulo Biennale. His art, which often explored themes of nature, human experience, and social issues, was celebrated for its emotional depth and balance between contrasts. Al-Zeini also contributed to public art projects like murals in the Cairo Metro and won awards such as first prize at the Alexandria Biennale in 1991. His legacy lives on through his influential contributions to Egyptian art and education.